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KMID : 0363320030240010021
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.21 ~ p.32
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Inhibitory Effect of Injinchunggantang(Yinchenqinggan-tang) on Hepatic Sclerosis
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Seung Hyun-Suk
Kim Young-Chul
Lee Jang-Hoon
Woo Hong-Jung
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Abstract
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Objective : The aim of this study is to investigate the inhibitory effect of Injinchunggantang on hepatic sclerosis induced by CCl_4.
Methods : Weight, liver function test and complete blood cell count, gross findings, and findings on liver tissue of the past(Hematoxylin & Eosin stain, Masson-Trichrome stain) were studied.
Results : When it comes to the change of rats’ body weight, The CCl_{4+}Injinchunggantang group lost far less weight than The CCl_{4-}only group. In the liver function test, which is focused on various areas such as total cholesterol, alkaline phosphotase, albumin, aspartate transaminase, alanine transaminase, The CCl_{4+}Injinchunggantang group was much more closer to normal limit than the CCl_4 only group. In the complete blood cell count, including white blood cell, red blood cell, hemoglobin, hematocrite, platelet, The CCl_{4+}Injinchunggantang group significantly closer to normal limit than CCl_{4-}only group. In the gross findings of hepatic fibrosis models, Injinchunggantang showed inhibitory effect on hepatic fibrosis in the order. In the past findings of hepatic fibrosis models in Hematoxylin & Eosin, Masson-Trichrome staining, the liver in CCl_{4-}only group showed atrophy and necrotic change with white nodules, whereas that of CCl_{4+}Injinchunggantang group showed lesser significant change with the well_preserved tone of the tissue. In the extent of the inhibition of the hepatic fibrosis, the Injinchunggantang group showed statistically significant inhibitory effect(p<0.05) in the sclerosis model.
Conclusions : These results show that Injinchunggantang have inhibitory effect on hepatic sclerosis induced by CCl_4 and further ultimately prevent liver cirrhosis. To obtain more credible results in this experiment, the invention of a new experimental model more similar to human hepatic sclerosis is still needed.
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KEYWORD
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Injinchunggantang, hepatic sclerosis, CCl_4
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